Tuesday, October 20, 2009

“Birkhead: Prosecutors Chastised Testimony - WKRG” plus 4 more

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“Birkhead: Prosecutors Chastised Testimony - WKRG” plus 4 more


Birkhead: Prosecutors Chastised Testimony - WKRG

Posted: 20 Oct 2009 07:41 PM PDT

Los Angeles, - The father of Anna Nicole Smith's daughter says he was criticized by a prosecutor for his testimony about the role Smith's former boyfriend had in her medication.

Larry Birkhead, whose romance with Smith began at a Kentucky Derby party, was questioned about the incident by a defense lawyer before his testimony resumed Monday in a preliminary hearing that will decide if Smith's former boyfriend, Howard K. Stern, and two doctors will face trial. They are accused of illegally giving the former Playboy model controlled substances.

Birkhead says Deputy District Attorney Sarah Slice called after he testified Friday and suggested he was taking Stern's side. He says she also suggested there was something wrong with his daughter because of Smith's drug use before she died in 2007.

Birkhead has testified that Smith took more drugs than anyone he had seen.

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Bethenny Frankel Pregnant With First Child - Transworld News

Posted: 20 Oct 2009 10:37 AM PDT

Atlanta, GA 10/20/2009 05:44 PM GMT (TransWorldNews)

Only days after announcing her engagement to boyfriend Jason Hoppy, Bethenny Frankel has announced she is pregnant with her first child. The Real Housewives of New York City star says she planned to wait to share the news because she is only 2 months pregnant, but internet buzz forced her to confirm the pregnancy.

"It's premature to be telling people this," she tells People magazine. "It's not like, 'Did I Get Botox?' It's not the way I wanted it to get out. I haven't even gone through my first trimester. We haven't even heard the heartbeat. My [fiancé's] parents didn't even know."

Though she is disappointed at the pregnancy news being released, Frankel says she and Hoppy are "both so excited" to become parents.

Frankel and Hoppy, both 38, plan to tie the knot before the baby arrives. Read more about the couple's engagement

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Psychiatrist Details Anna Nicole's Drug Addiction - NewsMax.com

Posted: 20 Oct 2009 05:25 PM PDT

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Psychiatrist: Anna Nicole Smith was addict - KOB.com

Posted: 20 Oct 2009 11:56 AM PDT

(AP) LOS ANGELES - A pharmacist testified Tuesday that he warned Anna Nicole Smith's psychiatrist against prescribing a powerful sleeping medication to the celebrity model after she had given birth to a daughter and endured the death of her son in 2006.

"I said, 'Unless you want your picture on the cover of the National Enquirer, I wouldn't give her (chloral hydrate) because it's a powerful respiratory depressant,'" pharmacist Steve Mazlin said he told Dr. Khristina Eroshevich.

Mazlin said Eroshevich purchased chloral hydrate and also asked for a rapidly acting anti-anxiety medication, and he recommended lorazepam.

An autopsy showed Smith died in February 2007 of an accidental overdose of chloral hydrate combined with other controlled substances.

Eroshevich is charged along with Dr. Sandeep Kapoor and Howard K. Stern, Smith's lawyer-boyfriend, with conspiring to provide controlled substances to Smith. All have pleaded not guilty.

The testimony came at a preliminary hearing to determine if they should stand trial.

Another pharmacist, Romeo V. Par, testified that Eroshevich came to his pharmacy in October, 2006 and obtained the drugs Xanax, Valium and klonopin for a patient named Charlene Underwood. Valium and klonopin also were implicated in Smith's overdose death.

The prosecution maintains Underwood was a pseudonym used for Smith, and they called to the stand a woman by that name who once did business with Eroshevich.

The judge, expressing impatience at the length of the hearing, hustled her on and off the stand and told prosecutors to begin moving their case along.

A hospital psychiatrist who treated Smith for drug dependency concluded two days on the stand saying the former Playmate fit the legal definition of an addict.

However, under questioning by a judge, Dr. Nathalie Maullin said she never used the words "addict" or "addiction" when discussing the celebrity model's problems with her, Kapoor and Stern.

Before leaving the stand, Maullin said she once asked Kapoor if he thought Smith was addicted. She said he chuckled and mentioned she had problems with alcohol.

The charging document in the case states that Stern, Kapoor and Eroshevich "acted with knowledge that Anna Nicole Smith was an addict." Prosecutors are trying to prove the defendants had that knowledge.

Maullin, who treated Smith during a brief hospital stay when she was pregnant in April, 2006, was quizzed by Superior Court Judge Robert J. Perry on the addiction issue.

"She was never trying to get high?" he asked.

"I never thought she was trying to get high. I think she wanted to tune out," the psychiatrist said.

The preliminary hearing will be recessed Wednesday, a mandated state furlough day for the court system.

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Classifying molar pregnancy - EurekAlert

Posted: 20 Oct 2009 09:21 PM PDT

[ Back to EurekAlert! ] Public release date: 21-Oct-2009
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Contact: Angela Colmone
acolmone@asip.org
301-634-7953
American Journal of Pathology

Baltimore, MD Researchers from The Johns Hopkins Medical Institutions have used short tandem repeat (STR) genotyping and p57 immunohistochemistry to distinguish hydatidiform moles. The related report by Murphy et al "Molecular Genotyping of Hydatidiform Moles: Analytic Validation of a Multiplex Short Tandem Repeat (STR) Assay," appears in the November 2009 issue of The Journal of Molecular Diagnostics.

Molar pregnancy is an abnormal form of pregnancy in which a fertilized but non-viable egg implants in the uterus, resulting in a hydatidiform mole. Hydatidiform moles, which occur in one in every 1000 pregnancies in the United States, increase the risk of persistent gestational trophoblastic disease (GTD) and choriocarcinoma, a malignant, rapidly-growing, and metastatic form of cancer. Molar pregnancies can have either partial or complete hydatidiform moles. Complete hydatidiform moles (CHMs) arise when an empty egg with no nucleus is fertilized by a normal sperm, and partial hydatidiform moles (PHMs) arise from a normal egg fertilized by two sperm.

CHMs, PHMs, and non-molar specimens (NMs) have different risks for persistent GTD, and thus differentiation is important for clinical treatment of patients. Morphological diagnosis results in high inter- and intra-observer variability; therefore, Murphy et al explore using genetic features to differentiate CHMs, PHMs, and NMs. They found that STR genotyping and p57 immunohistochemistry, by identifying the parental source of particular alleles, can distinguish CHMs, PHMs, and NMs and have developed an algorithm for the interpretation of STR data.

Dr. Murphy and her colleague Dr Brigitte Ronnett "have applied this algorithm in routine practice to ensure accurate diagnosis of hydatidiform moles. In doing so, they have determined that the genetics of molar specimens can be more complicated than traditionally thought." Drs. Murphy and Ronnett are now working to "discover additional risk factors for GTD, in order to identify women who may require chemotherapy."

Murphy KM, McConnell TG, Hafez MJ, Vang R, Ronnett BM: Molecular Genotyping of Hydatidiform Moles: Analytic Validation of a Multiplex Short Tandem Repeat (STR) Assay. J Mol Diagn 2009, 598-605

For press copies of the articles, please contact Dr. Angela Colmone at 301-634-7953 or acolmone@asip.org.

The Journal of Molecular Diagnostics, the official publication of the Association for Molecular Pathology, co-published by the American Society for Investigative Pathology, seeks to publish high quality original papers on scientific advances in the translation and validation of molecular discoveries in medicine into the clinical diagnostic setting, and the description and application of technological advances in the field of molecular diagnostic medicine. The editors welcome for review articles that contain: novel discoveries or clinicopathologic correlations including studies in oncology, infectious diseases, inherited diseases, predisposition to disease, or the description or polymorphisms linked to disease states or normal variations; the application of diagnostic methodologies in clinical trials; or the development of new or improved molecular methods for diagnosis or monitoring of disease or disease predisposition.



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